Posts Tagged ‘scotland’

Milk in pregnancy may lower MS risk

Tuesday, February 9th, 2010 | Tags: , , , , , , , ,
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Mothers-to-be can reduce their babies’ risk of developing multiple sclerosis in later life by drinking milk, research suggests.

The link emerged from a study of 35,794 female nurses whose mothers provided information about their diet during pregnancy. Of the nurses taking part, 199 developed multiple sclerosis (MS) over a 16-year period.

The researchers found that the risk of MS was lower among women born to mothers who drank a lot of milk while pregnant. A similar trend was seen for vitamin D. Mothers who had a relatively high vitamin D intake during pregnancy also gave birth to daughters with a reduced risk of MS.

Dr Fariba Mirzaei, from the Harvard School of Public Health in Boston, US, who led the study, said: “The risk of MS among daughters whose mothers consumed four glasses of milk per day was 56% lower than daughters whose mothers consumed less than three glasses of milk per month.

“We also found the risk of MS among daughters whose mothers were in the top 20% of vitamin D intake during pregnancy was 45% lower than daughters whose mothers were in the bottom 20% for vitamin D intake during pregnancy.”

She added: “There is growing evidence that vitamin D has an effect on MS. The results of this study suggest that this effect may begin in the womb.”

Exposure to sunlight, oily fish such as salmon and mackerel and fortified milk are key sources of vitamin D.

The research was presented at the American Academy of Neurology’s annual meeting in Toronto, Canada.

http://www.google.com/hostednews/ukpress/article/ALeqM5h6LXkXVsMbkT6Jpc603zVlyiX4Qg

Success at Parliament for schoolboy campaigner

Tuesday, February 9th, 2010 | Tags: , , , , , , , , , , , , , , ,
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Story by STV news

The Scottish Govenrment has made a series of key pledges relating to MS and vitamin D, following a petition by Ryan McLaughlin.

A schoolboy who set out to raise awareness of the medical condition suffered by his mother has spoken of his pride in securing a number of key pledges from the Scottish Government.

Ryan McLaughlin went to Holyrood’s Public Petition Committee last year to raise the issue of links between vitamin D and multiple sclerosis.

The 14-year-old’s petition called on ministers to produce new guidelines on vitamin D supplements for children and pregnant women, along with an awareness campaign about the issue.

The Scottish Government has now agreed to support and host a summit in April on the role of vitamin D. New guidance on supplements will also now be published. and to produce the guidance on supplements.

Ryan took up the cause a year ago after watching his mother Kirsten suffering the incurable disease. On Tuesday, the committee agreed to close his petition.

Ryan said: “After an amazing year in raising both vitamin D and MS awareness, I now have the commitments that I wanted from the Scottish Government.

“I applaud the positive action taken by the Scottish Government and the support from Deputy First Minister Nicola Sturgeon and Shona Robison, Health and Sports Minister.”

Ryan’s local MSP Bill Butler hailed the campaigning schoolboy’s achievement, saying “a very great deal of progress” has been made.

The Glasgow Anniesland politician hailed the way “Ryan and the McLaughlin family have persuaded the Government and the Government has listened to the very sensible suggestions contained in the petition”.

He said: “The Government has agreed to a co-ordinated programme of action with NHS Scotland to produce guidance on vitamin D, to educate women on its importance, to consider different messages for different groups of people and to ensure that health professionals are giving correct and consistent advice to pregnant women and new mothers in relation to vitamin D.”

He described that as a “significant success”, adding: “It’s people listening to what is a very sensible set of suggestions from someone whose personal circumstances have convinced him that there is need for reform here.

“It’s a success story.”

A spokeswoman for the Scottish Government said: “We’re keen to learn all we can about any possible links between vitamin D and multiple sclerosis and are keeping a very close eye on all the emerging evidence.”

http://news.stv.tv/scotland/156458-success-at-parliament-for-schoolboy-campaigner/

Multiple sclerosis risk changes with the season

Thursday, February 4th, 2010 | Tags: , , , , , , , , , , , , , , ,
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Previous studies have shown multiple sclerosis (MS) patients are more often born in spring than in any other season, indicating that there is an environmental risk factor for the disease. A paper in the journal Neurology, reviewed for f1000 Medicine by Emmanuelle Waubant and Ellen Mowry, now suggests that this seasonal effect is mediated by the gene HLA-DRB1.

In many European populations, the HLA-DRB1*15 allele of this gene is associated with an increased risk of MS, and the large-scale study of MS patients from Canada, Sweden and Norway now shows that this allele is more common among patients born in the spring.

Waubant and Mowry said the study was “unique in its attempt to understand how genes and environment interact in MS”. However, even though there is a correlation between birth month, genetics and risk of MS, it is not yet clear how this is regulated.

One likely contender is vitamin D, which influences expression of the HLA-DRB1*15 allele. Since vitamin D production fluctuates with the seasons, a vitamin D deficit in pregnant mothers could be related to the increased risk of MS among spring births, but this requires further investigation.

Waubant and Mowry said the study may influence preventative and therapeutic treatments through the understanding of environmental risks and their interaction with relevant genotypes.

Previous studies by the Neurology paper’s authors showed that in people who carry the gene variant, a lack of vitamin D during early life might impair the ability of the thymus to delete rogue T cells, which then go on to attack the body, leading to a loss of myelin on the nerve fibres.

Study author Dr Sreeram Ramagopalan said that taking vitamin D supplements during pregnancy may reduce the risk of a child developing MS in later life. The Scottish Government recently committed to producing a new education program for pregnant mothers and also issued a recommendation that all children under five take a daily vitamin D supplements in a written response to evidence given to the Scottish parliament petitions committe by 14 year old Ryan Mclaughlin from Glasgow and Dr Sreeram Ramagopalan.

Ryan Mclaughlin has been campaigning for every child in Scotland to get vitamin D as a preventative measure against MS.

Ryan Mclaughlin is due back at the Scottish parliament next week to hear the latest responses to his petition.

Ryan Mclaughlin will take the plunge for Glasgow MS Charity

Monday, February 1st, 2010 | Tags: , , , , , , , , , , , , , , , , , , ,
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big zip

14 year old Ryan McLaughlin will do a Zip slide from Forth Road bridge to raise money for Glasgow MS Charity!

Ryan McLaughlin from the Shine on Scotland campaign has offered his support and help to the Glasgow based charity Revive MS Support. Ryan McLaughlin will be taking part in ‘Revive MS support’s ” zip line event and he is gathering people from all over Scotland to help him.

Ryan said – I’ve been working very hard on the campaign for the prevention of MS with vitamin D that I just haven’t had any free time to do anything lately for Revive MS support, but when my mum had  a big relapse a couple of weeks ago Revive MS support was right there for us offering support and treatments.

I know its very important that I don’t forget this amazing charity that looks after my mum and i am honored to help, they have been there for our family right from the day she was diagnosed and I can not and will not let them down.

I have asked all the people on my Facebook  group to help me and I’m proud to say that I’ve now got 14 people that offered to come along do the zip slide and raise at least £100 each which will go towards my target of raising £1500.

A lovely couple who have followed my campaign and have became online friends with my mum have even offered to come all the way from the Isle of Man and take part because they have been so inspired by what the ‘Shine on Scotland’ campaign has achieved in raising awareness of MS.

http://www.revivescotland.org.uk/get-involved/26-adrenaline-events/276-davidrevivemssupportorguk.html

Should we all be taking vitamin D?

Monday, February 1st, 2010 | Tags: , , , , , , , , , , , , , , , , , , , , , , , , ,
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Dr Mark Porter: Should we all be taking vitamin D?

From The Times
February 1, 2010

New research showing that vitamin D may protect against cancer of the colon is the latest in a long line of studies suggesting that there is far more to this vitamin than its traditional role in helping to maintain healthy bones. And although this new study involved more than 500,000 people from ten different European countries, it is pertinent to the UK because so many of us have low levels of vitamin D — especially at this time of year.

So should more of us be considering supplements?

Vitamin D is required to help the body make proper use of calcium — the basic building block of bones — which is why interest in it has traditionally centred on rickets, a condition that results from severe deficiency. But we now understand that it does far more than maintain the skeleton, and that milder degrees of deficiency may predispose to a range of other illnesses including diabetes, lung disease, osteoporosis, multiple sclerosis (MS), rheumatoid arthritis, various cancers, and even Alzheimer’s disease.

The vitamin is manufactured in the skin when we’re exposed to sunlight but our northern latitude and short summers mean that for six months of the year UV levels are so low that most of us don’t make enough of the vitamin to meet basic requirements.

The problem is compounded by the use of sunscreens, which further reduce natural UV exposure during the summer months when vitamin D stores are replenished, and the popularity of supplements containing vitamin A (it is thought that as many as 1 in 5 of the population take one), which antagonise some of the D’s actions.

As well as manufacturing the vitamin in our skin, we also take it in from our diet. It occurs naturally in oily fish, such as tuna and herring, and liver, milk and eggs. In most industrialised countries it is added to margarine, some powdered milks, bread and breakfast cereals.

The scale of the potential problem is nicely outlined by researchers from the University of Sheffield, who looked at vitamin D levels in the cord blood of babies born at the hospital at the end of spring — the time when their mothers’ vitamin D stores were likely to be at their lowest. Seven out of ten of the babies had lower than ideal levels of vitamin D, 90 per cent of whom were white, dispelling the myth that deficiency is principally a problem in ethnic minorities with darker skin (the extra pigment reduces UV penetration even further).

Meanwhile in Finland researchers tracking a group of people born in the Sixties turned up evidence suggesting a link between low levels of vitamin D and Type 1 diabetes later in life. Children brought up in the gloomy winters of Finland are more than a hundred times more likely to develop the condition than their peers in sunny Venezuela. Since then UK research has shown that children given vitamin D supplements are around a third less likely to develop diabetes.

Vitamin D is a steroid and there are receptors on almost every cell in the body. Its link with diabetes could be explained by an action on receptors in the pancreas and on the various cells in the immune system, but there are similar vitamin D specific targets in almost every other organ, including the brain, heart, muscles, kidneys and, of course, the skeleton. Little wonder then that there is growing interest in the role of the vitamin in diseases, ranging from MS to Alzheimer’s.

Should we all be taking a supplement? It’s too early to tell whether mass supplementation is the way forward, but it is now widely agreed that the following key groups are those most likely to benefit:

Women who are pregnant or breastfeeding
Children under 5 (particularly breastfed infants)
The over-fifties
Vegetarians who don’t eat oily fish
Anyone who is housebound or who covers up when outside
Those who are dark-skinned — particularly Asians.

The standard dose for an adult is 10mcg day and trials looking at the safety of long-term supplementation have reported no adverse effects at intakes of more than double that. Much higher doses (50mcg a day or more) can weaken bones and increase the risk of calcium deposits (such as kidney stones) forming elsewhere.

During the summer most people will manufacture enough vitamin D by exposing their face and arms to the sun for an hour across the week. You don’t have to sunbathe, just accumulate around ten minutes of exposure while going about your normal business — assuming you are not wearing a sunscreen, or a moisturiser that contains one.

http://www.timesonline.co.uk/tol/life_and_style/health/expert_advice/article7008426.ece

50% of UK Vitamin D deficient

Friday, January 29th, 2010 | Tags: , , , , , , , , , , , , , , , ,
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Spending too long indoors, applying excessive sun screen and the changing ethnic population is causing precariously low levels of Vitamin D in parts of the UK, warn Professor Simon Pearce and Dr Tim Cheetham at Newcastle University.

“More than 50% of the adult population have insufficient levels of vitamin D and 16% have severe deficiency during winter and spring,” they say. “The highest rates are in Scotland, Northern Ireland and northern England. People with pigmented skin are at high risk as are the elderly, obese individuals and those with malabsorption.”

The research published in the British Medical Journal, has found that the most commonly affected are people of Asian and African descent who live in the North; a key part of the research focused on young Somalis who live in east Newcastle.

Other causes include consistent sun screen application instead of allowing 20 to 30 minutes exposure to the sun two or three times a weeks, staying indoors all the working day and children sitting in front of computer games rather than playing outdoors.

Pearce has written to the Department of Health proposing Vitamin D is added to milk. It is already added to artificial baby milk.

Rickets are associated with the 19th century and young workers in industrial cities. The disease causes softening of the bones and muscle weakness. When a child has rickets, there is not enough mineral in the bones, making them soft and weaker.

Some vitamin D is obtained from certain foods: egg yolk, liver, oily fish such as sardines, herring, tuna, salmon and mackerel. A diet low in these foods will contribute to a lack of vitamin D but the main cause of the problem is lack of sunlight on the skin.

Higher vitamin D levels may be linked to lower risk of bowel cancer

Monday, January 25th, 2010 | Tags: , , , , , , , , , , , ,
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25/01/2010

People with higher levels of vitamin D appear to be significantly less likely to develop bowel cancer, a new European study has found.

Researchers from a number of institutes in Europe, including Imperial College London, analysed data contained in the European Prospective Investigation into Cancer (EPIC) study, which involved over 520,000 people in ten countries.

Participants provided blood samples and information on their diet and lifestyle between 1992 and 1998, before being followed for several years.

At the time of the analysis, information from 1,248 people who had been diagnosed with bowel cancer was compared with information on 1,248 healthy controls also involved in the study.

The researchers discovered that people with the highest concentrations of vitamin D in their blood had a 40 per cent reduced risk of bowel cancer compared with those recording the lowest levels of the vitamin.

Writing in the British Medical Journal, the researchers concluded that vitamin D may be associated with a protective effect against bowel cancer.

However, they noted that insufficient research has been carried out into the long-term health impact of having high levels of vitamin D in the blood and that further research is needed both to confirm any beneficial effect on bowel cancer risk and to rule out any potential adverse effects.

Ed Yong, head of health evidence and information at Cancer Research UK, said: “This large study confirms that low levels of vitamin D are linked to an increased risk of bowel cancer. More research is needed to clarify whether vitamin D alone directly prevents this disease or if having higher levels of vitamin D means people are generally healthier.

“Either way, we know that vitamin D is important for good health,” he continued.

“Enjoying the sun safely while taking care not to burn should help people strike a balance between making enough vitamin D and avoiding a higher risk of skin cancer. People can also top up their vitamin D levels by eating foods like oily fish (such as salmon, trout or mackerel), or by taking supplements after talking to their GP.”

Reference

  • Jenab, M. et al (2010). Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case-control study BMJ, 340 (jan21 3) DOI: 10.1136/bmj.b5500

Study shows beneficial effects of fortified milk on child’s cognitive development

Friday, January 15th, 2010 | Tags: , , , ,
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Singapore, January 14, 2010: According to a study, fortification of milk given to children of preschool age showed significant improvement in cognitive and executive function at school age (6-8 years). This study, sponsored by Fonterra, the world’s largest dairy exporter from New Zealand, is a continuation of an initial study that was carried out to evaluate the effects of the same micronutrient fortified milk on morbidity in young, preschool children.

An intervention study was carried out to evaluate the effects of micronutrient fortified milk on cognitive function in young children. The participants included 375 children aged 6-8 years, randomly allocated to receive the fortified milk or control milk. The fortified milk included a specific combination of zinc, iron, selenium, copper and vitamins A, C and E.  Through the usage of the Wisconsin Card Sorting Test (WCST), children in the fortified milk group were found to have better cognitive and executive function. The fortified milk children exhibited: 14% lower odds of making errors,

The study examined the long term effects of early micronutrient supplementation for one year during the early preschool years on subsequent executive functioning of the children at ages of 6 to 8 years of age. Results showed that consumption of milk fortified with specific micronutrients was associated with improvement in sub-measures of executive functioning using WCST, as compared to the control group of children. These findings are consistent with previously reported observational studies of long-lasting benefits of early nutritional supplementation on cognition especially higher mental functions when the children reached school age.

Compared to the control group children, children who received the specific micronutrient intervention had 14 % lower odds (95% CI: 10-17%) of making errors, 8% lower perseverative errors (95% CI: 5-11%), and 10% lower non-perseverative errors (95% CI: 6-14%). The conceptual level responses were 26% higher (95% CI: 21-31%) in the micronutrient intervention group than the control group.

This study demonstrates beyond reducing the impact of acute childhood illness and improving nutritional status, consumption of specific fortified milk in early childhood showed improved cognitive ability later in life.

Prof Sunil Sazawal, a leading expert in child nutrition and health and has served as a World Health Organisation (WHO) consultant numerous times said, “Because nutrition plays such a vital role in the process of cognitive development, micronutrient deficiencies can have a serious impact. For example, deficiencies of iron and zinc, prevalent even among well-nourished children in Asian regions, are postulated to have a negative effect on the developmental potential of these children.”

Vitamin D shortage linked to bone fractures

Thursday, January 14th, 2010 | Tags: , , , , , , , , , ,
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by Melanie Reid

Doctors say that food fortified with vitamin D should be on sale in Scotland to help prevent the thousands of crippling hip injuries every year.

Studies carried out in Glasgow show that 98 per cent of people with hip fractures suffer from a serious shortage of the vitamin, which is vital for allowing calcium to strengthen the bones. Most people meet their vitamin D needs through exposure to sunlight, but it is also found in oily fish such as salmon and tuna, and egg yolks.

Stephen Gallacher, a consultant physician who is head of South Glasgow’s fracture liaison service, said yesterday that levels of the vitamin in Scotland were “frighteningly low”.

“Vitamin D seems to play a key role in many systems in the body, not just bones, but diseases like diabetes and certain cancers,” he said. “A serious shortage of vitamin D leads to a condition called osteomalacia, where your bone fails to mineralise.”

Vitamin D deficiency, he added, was linked to poor bone density and osteoporosis, and could occur in younger patients. Dr Gallacher said that among the hip fracture patients aged between 50 and 70 referred to him, most tended already to have very low bone density.

As people get older, their bodies become less adept at converting vitamin D from sunshine through their skin. To add to the problem, the diet in Scotland is traditionally low in vitamin D.

Dr Gallacher said: “In the United States, milk which is fortified with vitamin D can be purchased alongside ordinary milk and I think there’s an argument that it would be quite useful to do the same here. It makes logical sense to give people the choice.”

He welcomed the Scottish government’s recent move to raise awareness among pregnant women and young mothers about the importance of vitamin D.

Scotland now leads the world in following up cases of broken bones to trace their underlying cause and try to prevent further breaks. A fracture liaison service was pioneered in Glasgow in 1999. Now accessible to three quarters of the population of Scotland, the service means that anyone over 50 who suffers a fracture is automatically referred to have their bone density measured and, if low, their vitamin D level taken.

Those who have poor density, and are at risk of osteoporosis and further fractures, are treated with calcium and vitamin D supplements and other anti-osteoporosis therapies.

“We would like to have Scotland as the first country in the world with a comprehensive fracture liaison service,” said Dr Gallacher. “We’re 75 per cent of the way there and just need the financial investment to complete the loop. It would make Scotland a beacon for the rest of the world.”

Over ten years the service has proved cost-effective by averting further fractures through treatment. “Taking a supplement can make a difference quite quickly,” said Dr Gallacher. “Bone density can increase by 20 per cent in a few months with enough vitamin D,” he said.

“We have found we can reduce fractures by something like 30 to 50 per cent. It is our belief that we can significantly reduce the risk of fractures in the population by giving people anti-osteoporosis therapy and vitamin D supplements.”

Dr Gallacher’s research in Glasgow found near universal vitamin D inadequacy among more than 500 elderly patients with broken hips. The report also pointed out that in Iceland, where there is intensive dietary and lifestyle education, there is a much lower incidence of hip fractures.

The study would seem to demonstrate that “ vitamin D inadequacy represents a significant correctable risk factor for fragility fracture in our elderly population, and that the observed prevalence of inadequacy is substantially higher than in many other parts of the world”.

The current spate of bad weather has brought more cases to light. Dr Gallacher, who is based at the Southern General Hospital, said: “Falls are bad news, particularly for elderly patients.”

“Clearly the most serious of all is the hip fracture. Some elderly people will lose their independence as a result of hip fracture, and some, sadly, will not survive. A significant proportion of people with less serious fractures would also end up in hospital. “An old person who breaks her wrist may not be able to go home and look after herself and my end up in in-patients for a number of days.”.

He said his workload would increase over the next six weeks as people who had fractured bones in recent falls were referred to the fracture liaison service.

People born in April most at risk of MS

Monday, January 4th, 2010 | Tags: , , , , , , , , , , , , , , , , , , , , , ,
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New research suggests a link between a lack of sunlight and the disease

By Mark Macaskill

Babies born in April face the highest risk of suffering from multiple sclerosis in later life, according to a ground-breaking study that suggests pregnant mothers’ lack of exposure to sunlight may be to blame.

Scientists found mothers who were pregnant during the autumn and winter were most likely to give birth to those who would suffer from the debilitating neurological disease.

The researchers, based at Glasgow university and the city’s Southern General Hospital, believe the spike in cases among children born in the spring may be due to mothers being exposed to less sunshine at a vital stage in their unborn babies’ development.

Vitamin D, which is largely gained through sunlight and food, is known to regulate a gene that can predispose individuals to MS. If the gene is passed on to the unborn child, without being regulated by a sufficient amount of vitamin D, it could “hard wire” them to develop the disease in later life.

The new study, published in the European Journal of Neurology, is the biggest yet carried out in Scotland, which has the highest rate of MS in the world.

MS affects about 85,000 people in the UK and 10,500 in Scotland. While the cause is not known, experts believe a combination of genetic and environmental factors are responsible for the condition.

The Glasgow researchers examined data on about 1,300 MS patients born in the west of Scotland between 1922 and 1992. They found that about 400 people born in March, April and May went on to develop MS, 22% higher than expected. Almost half of all male and a quarter of female sufferers were born in April.

By comparison, there were about 16% fewer MS births in the autumn months. Those born in November had the lowest incidence of the disease.

Dr Colin O’Leary of the institute of neurological sciences at the Southern General and co-author of the study, said several theories about the condition were being explored.

“It’s a very interesting observation and springtime seems to be a period of relatively high risk,” he said.

“Seasonal risk may be a reflection of adverse events that occurred at the time of birth, in utero in the preceding nine months, or during the months following birth, when the central nervous system continues to undergo rapid development.

“There could be an association between reduced sun exposure and vitamin D levels.” O’Leary now plans to carry out a UK-wide study with scientists in Oxford.

Professor George Ebers, from Oxford university’s department of clinical neurology at the John Radcliffe Hospital, said: “The difference [in developing MS in Scotland] between being born in April versus November is an astounding 50%. This is real, there’s no doubt of a seasonal link. There are different theories, but I think the April excess of births could be linked to a sunlight deficiency.

“The focus is on trying to prove what the environmental effect is and, pending conclusive demonstration of that effect, some people might view it as prudent to conceive at certain times of the year to lower their child’s MS risk if there is a history of the disease in the family.”

Ryan McLaughlin, 14, from Glasgow, whose mother has MS, launched a campaign for all pregnant women and young children in Scotland to be given Vitamin D supplements.

A spokeswoman for the Scottish government, said: “Much of the evidence of a link between vitamin D and MS is still at a very early stage. We will continue to review all well-conducted research across the world. If the recommendations on vitamin D change we’ll make the appropriate arrangements.”

http://www.timesonline.co.uk/tol/news/uk/scotland/article6973890.ece